Maria Cristina Manara Selected Research

Ewing Sarcoma (Sarcoma, Ewing)

4/2022	Lamin A and the LINC complex act as potential tumor suppressors in Ewing Sarcoma.
1/2022	Integrated Molecular Characterization of Patient-Derived Models Reveals Therapeutic Strategies for Treating CIC-DUX4 Sarcoma.
1/2022	Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response.
1/2022	Targeting CD99 Compromises the Oncogenic Effects of the Chimera EWS-FLI1 by Inducing Reexpression of Zyxin and Inhibition of GLI1 Activity.
1/2021	Impact of ABC Transporters in Osteosarcoma and Ewing's Sarcoma: Which Are Involved in Chemoresistance and Which Are Not?
9/2020	Circulating miR34a levels as a potential biomarker in the follow-up of Ewing sarcoma.
1/2020	Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis.
1/2019	Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations.
3/2018	CD99 at the crossroads of physiology and pathology.
1/2018	Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99.

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Maria Cristina Manara Research Topics

Disease

32	Neoplasms (Cancer) 04/2022 - 03/2002
30	Ewing Sarcoma (Sarcoma, Ewing) 04/2022 - 03/2002
20	Osteosarcoma (Osteogenic Sarcoma) 01/2021 - 12/2002
10	Sarcoma (Soft Tissue Sarcoma) 01/2022 - 12/2002
7	Neoplasm Metastasis (Metastasis) 01/2022 - 03/2002
4	Disease Progression 09/2020 - 05/2011
3	Rhabdomyosarcoma 01/2011 - 03/2002
1	Giant Cell Tumors (Giant Cell Tumor) 06/2022
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2019
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019
1	Ovarian Neoplasms (Ovarian Cancer) 09/2017
1	Prostatic Neoplasms (Prostate Cancer) 06/2015
1	Rare Diseases (Rare Disease) 01/2013
1	Type 2 Diabetes Mellitus (MODY) 01/2013
1	Hypoxia (Hypoxemia) 01/2013
1	Thymoma (Thymic Carcinoma) 09/2012
1	Inflammation (Inflammations) 09/2012

Drug/Important Bio-Agent (IBA)

10	Pharmaceutical PreparationsIBA 01/2021 - 12/2002
6	Biological ProductsIBA 01/2021 - 03/2002
6	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018 - 09/2005
5	Cisplatin (Platino)FDA LinkGeneric 01/2018 - 12/2002
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 02/2014
4	TrabectedinIBA 01/2022 - 12/2002
4	IGF Type 1 Receptor (IGF 1 Receptor)IBA 09/2012 - 03/2002
4	Proteins (Proteins, Gene)FDA Link 01/2010 - 03/2002
3	MethyltransferasesIBA 01/2022 - 01/2018
3	Biomarkers (Surrogate Marker)IBA 09/2020 - 02/2013
3	MicroRNAs (MicroRNA)IBA 09/2020 - 04/2012
3	Insulin-Like PeptidesIBA 01/2020 - 09/2006
3	Messenger RNA (mRNA)IBA 01/2020 - 01/2010
3	Caveolin 1IBA 01/2019 - 04/2006
3	Insulin (Novolin)FDA Link 02/2014 - 01/2013
3	Vincristine (Oncovin)FDA LinkGeneric 01/2013 - 05/2005
3	Insulin-Like Growth Factor I (IGF-1)IBA 09/2012 - 01/2004
2	ZyxinIBA 01/2022 - 07/2004
2	MC3343IBA 01/2022 - 01/2018
2	Carrier Proteins (Binding Protein)IBA 01/2020 - 01/2010
2	quinolineIBA 01/2019 - 01/2018
2	EnzymesIBA 01/2019 - 01/2011
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019 - 12/2006
2	Membrane Proteins (Integral Membrane Proteins)IBA 03/2018 - 01/2018
2	CaspasesIBA 03/2018 - 07/2004
2	AntibodiesIBA 01/2013 - 09/2012
2	Somatomedin Receptors (Somatomedin Receptor)IBA 01/2013 - 01/2004
2	Metformin (Glucophage)FDA LinkGeneric 01/2013 - 01/2013
2	Insulin ReceptorIBA 01/2013 - 09/2012
2	NVP-AEW541IBA 09/2012 - 05/2005
2	Complementary DNA (cDNA)IBA 01/2008 - 04/2004
2	Phosphotransferases (Kinase)IBA 08/2007 - 05/2005
2	Methotrexate (Mexate)FDA LinkGeneric 09/2005 - 12/2002
2	Antineoplastic Agents (Antineoplastics)IBA 06/2004 - 12/2002
2	Alkaline PhosphataseIBA 04/2004 - 12/2002
1	Denosumab FDA Link 06/2022
1	Lamin Type A (Lamin A)IBA 04/2022
1	dactolisibIBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	EWS-FLI fusion proteinIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	MTOR InhibitorsIBA 01/2022
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2021
1	ChemokinesIBA 01/2020
1	Decitabine FDA Link 01/2019
1	Cadherins (E-Cadherin)IBA 01/2019
1	Azacitidine (5 Azacytidine)FDA Link 01/2019
1	Monoclonal AntibodiesIBA 03/2018
1	Clofarabine (Clolar)FDA Link 01/2018
1	Immune Checkpoint ProteinsIBA 09/2017
1	Immune Checkpoint InhibitorsIBA 09/2017
1	1,7- dimethyl- 1,4,7,10- tetraazacyclododecaneIBA 02/2014
1	maltolIBA 02/2014
1	Insulin Receptor Substrate ProteinsIBA 02/2014
1	12E7 AntigenIBA 01/2013
1	LigandsIBA 01/2013
1	Therapeutic UsesIBA 01/2013
1	Complement System Proteins (Complement)IBA 01/2013
1	Insulin-Like Growth Factor II (Somatomedin A)IBA 09/2012
1	IsoenzymesIBA 01/2011
1	O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfateIBA 01/2011
1	Glutathione Transferase (Glutathione S-Transferase)IBA 01/2011
1	6- (7- nitro- 2,1,3- benzoxadiazol- 4- ylthio)hexanolIBA 01/2011
1	Cytostatic AgentsIBA 01/2011
1	Environmental BiomarkersIBA 01/2010
1	Indicators and Reagents (Reagents)IBA 01/2010
1	LectinsIBA 01/2010
1	NF-kappa B (NF-kB)IBA 01/2008
1	Tyrosine (L-Tyrosine)FDA Link 08/2007
1	src-Family KinasesIBA 08/2007
1	Zoledronic Acid (Zometa)FDA Link 06/2007
1	NitrogenIBA 06/2007
1	ParaffinIBA 12/2006
1	Insulin-Like Growth Factor Binding Protein 3IBA 09/2006
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2006
1	CSK Tyrosine-Protein KinaseIBA 04/2006
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2006
1	4- demethoxy- 3'- deamino- 3'- aziridinyl- 4'- methylsulfonyldaunorubicinIBA 09/2005
1	Ifosfamide FDA LinkGeneric 05/2005

Therapy/Procedure

14	Therapeutics 01/2022 - 05/2009
9	Drug Therapy (Chemotherapy) 01/2021 - 12/2002
1	Precision Medicine 01/2013
1	Neoadjuvant Therapy 12/2006